PHARMACEUTICAL APPLICATION OF MICROSPHERES: AN APPROACH FOR THE TREATMENT OF VARIOUS DISEASESAbstract
Now a day the recent development in new drug delivery systems plays a vital role in pharmaceutical industries. The drug delivery practice has been modified in the last decades and even many advanced innovations happened in recent times. Newer drug delivery systems are largely influencing the current medical practice. Alterations of a traditional or conventional drug delivery into a new drug delivery system can absolutely changing the bioavailability, safety and efficacy of the drug and also it can produce improved patient compliance. Now a day, the scope of controlled drug delivery system is tremendously influencing the pharmaceutical dosage forms because it offers a wide range of products. Out of all controlled release products, Microspheres is one among all because of the controlled release and sustained release properties. This paper focus on the various types of microspheres along with their method of preparation and basic technique to evaluate its efficiency with most important emphasizes on pharmaceutical application of microspheres by means of microspheres taken by various routes of system such as oral, trasnsdermal, parenteral etc. Radioactive labelled microspheres found to attain more medicinal importance for the treatment of disease with labelled isotope tagging. Beside this Fluorescent microspheres can be used for membrane based technology flow cytometry, cell biology, fluorescent linked immuno sorbent assay. Isotope of Yttrium 90 can be used for primary treatment of cancer causing diseases and also used for pre transplant management of Hepato cellular Carcinoma with promising results.