PHARMACOGNOSTICAL OVERVIEW ON TERMINALIA ARJUNA: A JUSTIFICATION OF FOLKLORIC BELIEFAbstract
The application of medicinal plants such as Terminalia arjuna to maintain health and treat disease started since time immemorial and still is a part of medical practice. The phytochemical analysis of bark of T. arjuna in methanolic, hydromethanolic (1:1), aqueous and petroleum ether extracts revealed the presence of carbohydrates, amino acid, alkaloids, saponins, tannins, flavonoids, terpenoids, glycosides, xanthoproteins and phenols. In-vitro antioxidant capacity by linear regression analysis was measured by assaying DPPH radical and H2O2 scavenging capacities. Their respective IC50 values were found to be 336.89 μg/ml and 253.01 μg/ml. The hydromethanolic extract gave total phenolic, total flavonoids and FRAP values of 754.16 ± 16.26 mg GAE/g, 247.02 ± 8.81 mg/g QE/g and 1.36 ± 0.03 mM FeSO4 respectively. The IC50 values for in-vitro anti-inflammatory activities were evaluated by the following assays: lipoxygenase inhibition (IC50 = 480.5 μg/ml), heat induced protein denaturation (IC50 = 282.32 μg/ml), proteinase inhibition (IC50 = 1339.3 μg/ml) and RBC membrane stabilization (IC50 = 192.81 μg/ml) at different concentrations using aspirin as control. Studies were also carried out to assess the hypoglycemic potential by assaying the ability of the plant to inhibit alpha amylase (IC50 = 210.91 μg/ml) and pancreatic lipase (IC50 = 51.52 μg/ml) activities. In addition, glucose binding capacity and glucose diffusion was also monitored). Antimicrobial activity of the extracts was studied against common pathogens. The zone of inhibition was observed using well diffusion method.
Alisha, M. R. Dsouza * and N. Sonia
Department of Chemistry (P.G. Biochemistry), Mount Carmel College Autonomous, Bengaluru, Karnataka, India.
25 April, 2018
15 June, 2018
20 June, 2018
01 December, 2018