PHARMACOGNOSTICAL, PHYTOCHEMICAL EVALUATION AND ANTIINFLAMMATORY ACTIVITY OF STEM OF KALANCHOE PINNATA PERS.Abstract
Kalanchoe pinnata (Crassulaceae) commonly known as Jakh me hayat. Kalanchoe pinnata pers is present naturalized throughout the hot and moist parts of India, particularly common in Bengal. The plant is antibacterial, Anticancer, Antiparasitic, Anti-insecticidal, Anti-allergic. Phytochemical studies had revealed the presence of alkaloids, flavonoids, triterpenes, glycosides, steroids and lipids. Present study was carried out to determine, the morphological, microscopical and phytochemical profiles. Microscopy of stem show endodermis cortex, collateral types of vascular bundle and lignified xylem vessels, etc. The physical parameter such as ash value and extractive value were evaluated. The anti-inflammatory effect of 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4h H chromen-4-one isolated from the medicinal herb Kalanchoe pinnata pers stem, was evaluated for its anti-inflammatory activity in the Swiss albino-induced rat paw oedema models of acute inflammation. Flavonoid at doses of 200 and 400 mg/kg, the clinical anti-inflammatory indomethacin at 10 mg/kg, or vehicle were administered orally before injection of the pro-inflammatory compound. The test compound showed significant anti-inflammatory activity against paw edema induced by carrageenin, most notably at the highest test dose of 400 mg/kg. In these assay, the flavonoid compound was more active at 400 mg/kg.
Om Satyam Chaturvedi*, Amit Joshi and Bal Krishna Dubey
Department of Pharmacognosy, TIT-College of Pharmacy, Anand Nagar, Bhopal – 462021, Madhya Pradesh, India
21 December, 2011
28 January, 2012
21 March, 2012
01 April, 2012