PHARMACOKINETIC STUDIES OF SECNIDAZOLE IN THE PRESENCE OF PIPERINE AND ITS SYNTHETIC DERIVATIVEAbstract
Piperine has been widely used as a bioenhancer. Secnidazole is a long-acting 5-nitroimidazole analog. It is used in the treatment of amoebiasis, giardiasis, trichomoniasis and anaerobic bacterial infection. In this study derivative of piperine was synthesized and studied for its bio enhancing the effect and this effect was compared with the bioenhancing effect of piperine. The pharmacokinetic profile of Secnidazole alone and in combination with piperine and piperine derivative was investigated by validated bioanalytical HPLC method as per USFDA guidelines. It was observed that the synthesized derivative of piperine significantly improved the bioavailability of Secnidazole compared to piperine alone in Wistar rats. The N,N-diallyl-5-(benz)(1,3)dioxol-5-yl)penta-2,4-dienamide (DA) derivative showed 1.49 fold increase in the bioavailability of Secnidazole. After oral administration of Secnidazole alone and in combination with piperine and piperine derivative (0.035 mmol, 10 mg/kg) there was a significant increase in AUC and Cmax of Secnidazole.
P. Auti, S. Gabhe * and K. Mahadik
Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra, India.
09 July 2018
05 September 2018
15 September 2018
01 March 2019