PHARMACOLOGICAL AND ANTIBACTERIAL ASPECT OF PSIDIUM GUAJAVA L. AGAINST ACNE VULGARISAbstract
Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and noninflammatory (comedones, open and closed) lesions. A lot of factor viz; hormone, increased sebum production and diet causes Acne vulgaris but bacteria are the chief causal organism in which Propionibacterium acnes and Staphylococcus epidermidis are considered as the major skin bacteria that cause the formation of acne. The present study was conducted to evaluate the in vitro antimicrobial activities of Psidium guajava L. leaves essential oil against Propionibacterium acnes and Staphylococcus epidermidis. Extraction of essential oil was carried out using Clevenger’s Apparatus. Antibacterial activities of essential oil of leaves were investigated using broth micro dilution methods recommended by CLSI. The results showed that Guava leaves oils more effectively inhibit the growth of P.acnes (MIC: 0.321, IC50:0.309 mg/ml) as compared to S. epidermidis (MIC: 0.486, IC50:0.416 mg/ml). The readings were compared by standard drug tetracycline.
M. Pandey, A. Qidwai, R. Kumar, A. Pandey, S. K. Shukla, A. Pathak and A. Dikshit *
Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, Uttar Pradesh, India.
07 July, 2016
07 November, 2016
09 November, 2016
01 January, 2017