PHARMACOLOGICAL AND PHYTOCHEMICAL EVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF SOLANUM NIGRUMAbstract
Anti-ulcer activity of the Solanum nigrum L. extracts was studied in rats by using pylorus ligated ulcer model. Rantidine was used as the standard drug for comparison. The animals were sacrificed after 19 hrs after the ligation. Stomach was dissected out and contents were drained into tubes and were centrifuged at 1000 rpm for 10min and volume was noted. The PH of gastric juice was recorded using a PH meter. The contents were subjected for analysis of free and total acidity. The numbers of ulcers per stomach was noted and severity of ulcers scored. Then the blood samples were collected and subjected to estimation of serum calcium and alkaline phosphatase level. The results revealed that 200 and 400mg/kg dosages of Solanum leaf extracts showed significantly comparable anti ulcer-activity as that of Rantidine, showing an anti-ulcer activity of the extracts. Thus Solanum nigrum leaves may reduce the acidity of the gastric juice and also prevent the mucosal damage and ulcer formation.
G.G. Kavitha Shree*, S. Parvathi , P.S.S. Ramkumar , S. Shanmuga Priya
Senior Research Fellow, Department of Home Science Extension, Home Science College and Research Institute, Tamil Nadu Agricultural University, Madurai- 625 104, Tamil Nadu, India
27 April, 2012
25 June, 2012
27 July, 2012
01 August, 2012