PHARMACOLOGICAL EVALUATION OF POLYHERBAL SUSPENSION FOR ANTI-PARKINSONS ACTIVITY IN ALBINO RATAbstract
The ethanolic extract of Terminalia chebula extract obtained from successive extraction of Rosa damascene by Methanol; n-hexane & n-butanol was subjected to various phytochemical tests. The antioxidant activity was accessed by DPPH method. The anti-Parkinson’s activity was tested in albino Rats. Thirty albino rats (180-250 g) of either sex were divided into five groups and each group consist of six animal (n = 6). Group I: Normal Control (received 0.9% normal Saline) Group II: Disease control (Received Haloperidol 2 mg/kg i.p. single dose for 11 days). Group III: (Received Haloperidol 2 mg/kg i.p. single dose for 11 days) treated with standard drug Levodopa 6 mg/kg p.o continued for the next 45 days. Group IV: (Received Haloperidol 2 mg/kg i.p for 11 days) treated with polyherbal (Terminalia chebula & Rosa damascena) suspension at dose of 100 mg/kg p.o for next 45 days. Group V: (Received Haloperidol 2 mg/kg i.p for 11 days) treated with polyherbal (Terminalia chebula & Rosa damascena) suspension at 200 mg/kg p.o for next 45 days. After 45 days the locomotor efficiency was assessed by acto-photometer, stair case and rota rod apparatus. Statistical analysis obtained by different animal models revealed that the polyherbal suspension is effective against the PD. Treatment with polyherbal suspension at low dose (100 mg/kg) and high dose (200 mg/kg) compared to disease control group. Our study suggests that poly-herbal suspension is neuro-protective & inhibits the oxidative stress with no side effect. The polyherbal formulation can be used to treat Parkinson like symptoms.
A. Kumar and K. Mishra *
Hygia Institute of Pharmaceutical Education & Research, Lucknow, Uttar Pradesh, India.
25 August 2019
08 February 2020
19 March 2020
01 August 2020