PHARMACOLOGICAL EVALUATION OF SODIUM DIETHYLDITHIOCARBAMATE TRIHYDRATE AS NEPHROPROTECTIVE POTENTIAL IN RATSAbstract
Objective: The present study was carried out to evaluate the pharmacological evaluation of SDDCT as nephroprotective potential in rats. Material and Methods: The current study was designed to evaluate the pharmacological potential of SDDCT in Gentamicin induced nephrotoxicity in rats. The SDDCT found to be useful in suppression of nephrotoxicity. The pharmacological potential was evaluated in gentamicin 100 mg/kg induced nephrotoxicity in rats for seven days through i.p. administration, the effect of SDDCT at a different dose level that is a higher dose (100 mg/kg b.w. p.o.) and lower dose (50 mg/kg b.w. p.o.). Various physical, biochemical, and antioxidant parameters were studied. Gentamicin induced glomerular destruction, accumulation of inflammatory cells, epithelial desquamation and necrosis in parts of medulla was found to reduce in the groups receiving SDDCT along with Gentamicin. SDDCT also normalized Gentamicin induced increase in serum creatinine (0.40 ± 0.15), serum urea (30.33 ± 2.21), serum uric acid (1.80 ± 0.27) and blood urea nitrogen (16.06 ± 1.50) levels. This is also evidenced by histopathological studies. Result and Discussion: The nephroprotective activity of SDDCT was determined by comparing diseased group and treatment group with reference and standard group on the basis of improvement in elevated levels of biomarkers such as; BUN, Creatinine, Urea, Uric acid, decrease in level of MDA and increase in level of SOD, catalase and GSH. At last, it was observed that a high dose (100 mg/kg) of SDDCT was more significantly effective as compared to the low dose (50 mg/kg) on the basis of an evaluation of overall biological parameters and histopathological activities.
A. Sharma, H. Maurya, U. V. S. Sara and K. Mishra *
Hygia Institute of Pharmaceutical Education & Research, Lucknow, Uttar Pradesh, India.
30 September 2019
08 February 2020
10 March 2020
01 August 2020