PHARMACOLOGICAL SCREENING OF ANTIULCER AGENTS: A REVIEWAbstract
Gastric hyperacidity and gastro duodenal ulcer is a very common global problem today. Among various causes of gastric ulceration lesions caused by stress, alcohol consumption, H.pylori infection and use of NSAIDs have been shown to be mediated largely through the generation of reactive oxygen species (ROS), especially hydroxyl radical (*OH). Hyper secretion of gastric acid is a pathological condition, which occurs due to uncontrolled secretion of hydrochloric acid from the parietal cells of gastric mucosa through the proton pumping H+ K+ ATPase. The modern approach to control gastric ulcer is to inhibit gastric acid secretion, to promote gastro protection, to block apoptosis and stimulate epithelial cell-proliferation for effective healing. On contrary most of the green pharmaceuticals reduces the offensive factors and have proved to be safe, clinically effective, better patient tolerance, relatively less expensive and globally competitive.
Neetesh K Jain*, Namrata Singh, Pushpendra Kannojiya, Navneet Garud, Akanksha Garud and S D Tonpay
Department of Pharmacology, G R Medical College, Gwalior (M.P.), India
14 May, 2010
18 August, 2010
30 August, 2010
01 September, 2010