PHENOLIC ACID DERIVATIVES AS PRESERVATIVES: SYNTHESIS, ANTIOXIDANT, ANTIMICROBIAL POTENTIAL AND THEIR PRESERVATIVE EFFECTIVENESSAbstract
Natural phenolic acids alkyl esters viz methyl, ethyl, propyl was synthesized and characterized by spectral means FTIR, 1HNMR, and 13CNMR. All the synthesized esters were examined for their antimicrobial potential, preservative efficacy and antioxidant potential. Among the synthesized ester derivative caffeic acid and gallic acid, derivatives were displayed excellent antioxidant and antimicrobial potential. They were further evaluated their preservative efficacy according to USP 2004 protocol for preservative effectiveness testing. Caffeic acid propyl ester and gallic acid ethyl ester exhibited promising preservative potential better than existing preservative agents. From the study, we can conclude that these caffeic and gallic acid derivatives can be used as lead compounds to further explore their application as preservative agents in pharmaceuticals and in the food industry.
Sumit Sigroha, Amit Lather and Anurag Khatkar *
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
22 November 2020
12 March 2021
22 June 2021
01 October 2021