PHOSPHATIDYLCHOLINE: A REVOLUTION IN DRUG DELIVERY TECHNOLOGYAbstract
In recent years Phosphatidylcholine has greatly impacted the drug delivery technology. The very first and most important advantage of phospholipid based vesicular system is the compatibility of phospholipids with membrane of human either internal membrane as well as skin (external membrane). For a drug to be absorbed and distributed into organs and tissues and eliminated from the body, it must pass through one or more biological membranes/ barriers at various locations. Such a movement of drug across the membrane is called as drug transport. For the drugs to be delivered to the body should cross the membranous barrier. Either it would be from oral route or topical/transdermal route. Therefore the phospholipid based carrier systems are of considerable interest in this era. A number of drug delivery systems are based entirely on Phosphatidylcholine such as Liposome, Ethosome, Phytosome, Transferosomes, and Nanocochelates.
P. VERMA *, A. RAM, A. K. JHA, A. MISHRA, A. THAKUR
Shri Shankaracharya Institute of Pharmaceutical Science*, Bhilai (C.G.), India
4 January, 2010
20 January, 2010
28 January, 2010
01 February, 2010