PHYSICOTECHNICAL PROPERTIES OF PARACETAMOL TABLETS FORMULATED WITH THE GUM FROM THE FRESH LEAVES OF CORCHORUS OLITORIUSAbstract
Corchorus olitorius L. belongs to the family Tiliaceae. It is a plant with diverse medicinal uses. Its leaves when used to cook, give rise to a ‘slimy, viscous’ soup, hence the interest in investigating its binding properties. Gum was extracted from its leaves using standard procedures. The extracted gum was then used to prepare paracetamol tablets using concentrations of 1%, 2%, 4% and 6% respectively. Its pharmaco-technical properties: friability, hardness, weight uniformity, disintegration time, percentage of fines, and angle of repose, were determined and compared with that of paracetamol produced from a commercial binder- Sodium carboxymethylcellulose (SCMC). The results obtained showed great promise and a comparative efficacy between the gum extract obtained from Corchorus olitorius L. and the SCMC.
U.E. Osonwa, E.M. Uronnachi*, C.E. Umeyor and C.C. Onwuzuligbo
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
16 April, 2012
15 May, 2012
29 July, 2012
01 August, 2012