PHYTOCHEMICAL AND PHARMACOLOGICAL INVASTIGATION ON THE LEAVES OF TAMARINDUS INDICA LINN. FOR ANTILITHIATIC ACTIVITYAbstract
The main objective of the present investigation is to evaluate theantilithiatic activity of ethanolic extract of Tamarindus indica L. on mice. Antilithiatic activity of the ethanolic extract of the Tamarindus indica leaves at a dose of 250mg/kg, 400mg/kg & 500mg/kg was evaluated against the standard drug Cystone was given orally 750mg/kg. Adult Wister Albino rats of either sex of divided in six groups of six animals each as undertaken for study and evaluated by Rat models of calcium oxalate urolithiasis induced by either ethylene glycol (EG) are most commonly used to study the pathogenesis of urolithiasis.
Ethanolic extract of Tamarindus indica (at 250, 400 and 500 mg/kg) exhibited a dose dependent significant anti-lithiatic activity on treatment. The extract dose of 250 mg/kg also caused partial reduction of Uria, Uric acid, calcium, Potassium, oxalates, phosphorus and creatinine in blood serum level the results were found statistically insignificant. The antilithiatic effect of ethanol extract at was found less effective than the reference standard.
Beena Goyal* , Shashi Alok , S.K. Jain , Amita Verma and Mayank Kumar
Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India
11 March, 2013
10 July, 2013
14 November, 2013
01 January, 2014