PHYTOCHEMICAL CHARACTERIZATION ANDANTI-BACTERIAL EFFICACY OF MULTI-SOLVENT EXTRACTS OF WOODFORDIA FRUTICOSAL AGAINST ANTIMICROBIAL RESISTANT KLEBSIELLA PNEUMONIAE
AbstractThe current research focused on the extraction of phytochemical compounds form Woodfordia fruticosa using n-hexane, methanol, ethanol, chloroform, water, petroleum ether and acetone. The presence of bioactive compounds in different extracts was determined by the thin layer chromatography. The antimicrobial activity of various extract at different concentration was assayed by disc diffusion assay. The results revealed that ethanol, methanol and chloroform extracts of Woodfordia fruticosa inhibited the growth of K. pneumoniae AMR strains. Ethanol and methanol extract showed good antioxidant activity of IC50 375 ug/mL and 2938 ug/mL respectively. The molecular docking analysis also revealed that ellagic acid binds with OmpA with binding energy of -7.1 Kcal/mol and myricetin with MrkD with -6.9Kcal/mol.
Article Information
25
3585-3595
1884 KB
7
English
IJPSR
Suraj V. Kombe, Namrah Ameen Abdul Mateen, Subhash R. Somkuwar, Amol M. Kanampalliwar and Alok R. Rai *
Department of Microbiology, Seth Kesarimal Porwal College, Kamptee Nagpur, Maharashtra, India.
suraj.kombe@gmail.com
16 July 2026
05 October 2026
25 October 2026
10.13040/IJPSR.0975-8232.17(11).3585-95
01 November 2026
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