PHYTOCHEMICAL EVALUATION AND ANTIMICROBIAL ACTIVITY OF ETHANOLIC EXTRACT OF VISMIA GUIANENSIS (AUBL.) CHOISYAbstract
Studies have been demonstrating that Vismia guianensis (Aubl.) Choisy, popularly known as seal, a species native to South America has high anticancer and antimicrobial potential. The objective of this study was to evaluate the antimicrobial activity of the ethanolic extract obtained from the leaves of V. guianensis, and trace its chemical profile. The phytochemical screening showed the presence of different phenolic compounds in the extract. The high performance liquid chromatography performed on the sub-fractions A and B from the ethyl acetate fraction traced the chemical composition profile of the ethanol extract, composed by benzophenone, xanthones and anthraquinones. The antimicrobial activity of the extract evaluated by agar diffusion method showed inhibition against Gram-positive bacteria: Streptococcus mitis (ATCC 903), Streptococcus sanguis (ATCC 10557) and Staphylococcus aureus (ATCC 6538) and the fungi: Candida albicans (ATCC 40175), Candida krusei (ATCC 40147) and Candida parapsilosis (ATCC 40038).
Sarah Regina Pereira Camelo , Russany Silva Costa , Roseane Maria Ribeiro-Costa , Wagner Luiz Ramos Barbosa , Flavio Vasconcelos , Jose Maria dos Santos Vieira and Jose Otavio Carrera Silva Junior*
Adj. Prof., School of Pharmacy, Federal University of Para, University City, “Jose da Silveira Netto”, CEP 66075-110, Belem, Para, Brazil
17 August, 2011
04 October, 2011
16 November, 2011
01 December, 2011