PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC AND THROMBOLYTIC ACTIVITY OF THE CRUDE METHANOLIC EXTRACT OF CALAMUS ROTANG L. LEAVES (ARECACEAE)Abstract
Medicinal plants abound with many phytochemicals that are effective in representing lots of pharmacological activities. The current study aimed at investigating the phytochemical and pharmaco-logical activity of crude methanol extract of Calamus rotang L. (CRME) leaves. The analgesic activity and thrombolytic activity were examined by the acetic acid-induced writhing method, while the clot lysis effect was evaluated by an in-vitro thrombolytic method. From this study, it is stated that the extract (400, 200 mg/kg) reduced abdominal writhing by 31.06% and 44.33% for 200 mg/kg and 400 mg/kg respectively while the standard showed 58.57% of inhibition and increased the pain reaction time in mice when compared to that of the negative control group in tail-immersion test. The extract presented 16.2 ± 1.75% of human blood clot lysis in the thrombolytic experiment. The presence of steroids, saponins, glycosides, cardenolides, flavonoids, carbohydrates, and reducing sugars might have an influence on the pharmacological activity of CRME.
S. R. Afrin, S. Mitra, B. H. Khanam, M. R. Islam, N. M. Proma and M. K. Hossain *
Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh.
16 September 2019
31 January 2020
10 March 2020
01 September 2020