PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF EXTRACTS OF AZADIRACHTA INDICA A. JUSS (MELIACEAE) (CÔTE D’IVOIRE)Abstract
The purposes assigned to this work are the phytochemical screening of certain phytoconstituents, the estimation of the antioxidant and antibacterial activities of extracts of Azadirachta indica A. Juss. The selective extracts obtained from the aqueous decocts were used to establish the chromatographic profile of the various extracts. As for the crude aqueous extracts, they were used to carry out the tests by color reactions to evaluate their antioxidant potential as well as their antibacterial activity against 12 strains. Phytochemical screening revealed the existence of a few bio-important phytoconstituents. The median effective reduction concentration (CR50 = 0.10 mg / mL) demonstrated the antioxidant efficacy of trunk bark decocted (ET) vis-à-vis DPPH, compared with vitamin C (CR50 = 0.006 mg / mL), the reference antioxidant. Also, the extracts, in particular ET, exhibited almost bactericidal activity against the strains tested with the exception of Pseudomonas aeruginosa 469 UB / 20 CNRa. Both the antioxidant and the antibacterial activity of the plant vary depending on the type of extract, organ and bacterial strain.
Kadja Amani Brice *, Atsain-Allangba Marie Rosine, Kouassi Kouassi Stéphane, Mamyrbékova-Békro Janat Akhanovna and Békro Yves-Alain
Laboratoire de Chimie Bio-Organique et de Substances Naturelles / UFR-SFA / Université Nangui Abrogoua, 02 BP 801 Abidjan 02.
30 March 2021
25 May 2021
02 June 2021
01 January 2022