PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND IN-VITRO ANTICANCER ACTIVITIES OF TINOSPORA CORDIFOLIA LEAVES EXTRACTS
AbstractGlobally, cancer is a disease that is affecting the human population in abundance. According to the traditionally ayurvedic literature, Tinospora cordifolia are commonly applied in the treatment of various diseases. The present study was designed to investigate the antioxidant and anticancer activities of Tinospora cordifolia on the basis of its on biochemical and histopathological parameters. These included estimations of lipid peroxidation, CAT activity, GSH level, micronucleus assay and histopathological studies. In this study, phenolic and flavonoid content was found in leaves of Tinospora cordifolia. Cyclophosphamide (75 mg/kg; i.p.) is anticancer drug but it was used to induce dominant lethal mutation, micronuclei, DNA damage and generation of reactive oxygen species (ROS) in bone marrow for the estimation of antioxidant and anticancer activity. 5-Fluorouracil (30 mg/kg; i.p.) used as a standard, and ethanolic and aqueous extract of Tinospora cordifolia (250mg/kg, 500 mg/kg, 1000mg/kg; p.o.) is used as a preventive therapy. This study concluded that, both extract of T. cordifolia exerts antioxidant and anticancer activity.
Article Information
25
1485-1496
1147 KB
235
English
IJPSR
Pradeep Kumar Samal *, Mohanish Sharma, Bharti Vaishnaw, Aarti Tiwari, Kamdev Sen, Dipendra Nirmalkar and Pameshwar Kumar
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.
samalpharmacology@gmail.com
02 November 2023
04 January 2024
05 April 2024
10.13040/IJPSR.0975-8232.15(5).1485-96
01 May 2024
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