PHYTOCHEMICAL SCREENING, IN-VITRO MEMBRANE STABILIZING AND THROMBO-LYTIC ACTIVITIES OF LOPHOPETALUM JAVANICUM
AbstractIn the present study, different extracts of Lophopetalum javanicum (Zoll) leaves were evaluated for erythrocyte membrane stabilizing and thrombolytic activities. Phytochemical analysis of the plant was also performed to detect presence of different kinds of phytoconstituents. In order to predict anti-inflammatory activity the plant extracts were subjected to check erythrocyte membrane stabilization using heat and hypotonic solution induced hemolysis method. The crude methanolic extract, the aqueous and chloroform, pet-ether soluble fractions of L. javanicum leaves demonstrated strong membrane stabilizing activity compared to acetyl salicylic acid. In thrombolytic study, the crude methanolic extract, pet-ether, chloroform and carbon tetrachloride soluble fractions demonstrated strong thrombolytic activity in human blood specimen. Phytochemical screening revealed the presence of flavonoids, steroids, tannins and triterpenoids as major constituents in the extracts of the plant which may be responsible for the observed biological effects.
Article Information
7
350-353
311KB
1238
English
IJPSR
Md. Reyad-ul-Ferdous, Md. Golam Azam* and Md. Delower Hossain
Department of Pharmacy, North South University, Dhaka-1229, Bangladesh
mg_azam@yahoo.com
21 August, 2013
11 December, 2013
17 January, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).350-53
01 February, 2014
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