PHYTOPHARMACOGNOSTICAL STUDY OF SOME SELECTED ANTITUBERCULOSIS PLANTS AND STUDY OF ITS CYTOTOXICITY SCREENING USING VERO CELL LINEAbstract
Tuberculosis (TB) is one of the leading infectious diseases and health burdens in the world. One-third of the world’s population, including 40% from India, is estimated to be infected with tuberculosis. Current studies have indicated the urgent need for the development of new, safe, and efﬁcacious drugs to help reduce the global burden of tuberculosis. Novel antimycobacterial scaffolds from natural products have recently been reported. Natural products of plant biodiversity have received considerable attention as potential anti-TB agents since they are a proven template for the development of new molecules against tuberculosis. We have selected eleven medicinal plants on the basis of four criteria to choose a plant for antituberculosis activity. The plants were having antituberculosis effect, hepatoprotective effect, immune-modulatory action, and having the ability to enhance bioavailability. All selected eleven plants were reviewed in ancient literature and research article-based review. So here, our objective is to study pharmacognostic, physochemical and cytotoxicity screening of eleven selected medicinal plants. There are three different extracts of eleven selected medicinal plants that were prepared on the basis of phytochemical screening performed for the confirmation of the presence of active constituents. All the parameters of pharmacognostical study and physicochemical parameters compared with standards and results were within the range of limits. Cytotoxicity screening of all extracts of elevn selected plants were performed, and none of the extracts from eleven selected medicinal plants shows any significant cytotoxicity. So further, these all extracts of pants can be taken for antituberculosis screening.
K. Jethva *, D. Bhatt and M. Zaveri
K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.
17 March 2020
06 August 2020
16 August 2020
01 March 2021