PIM-1 KINASE: A NOVEL TARGET FOR CANCER CHEMOTHERAPY- A REVIEWAbstract
Cancer is the major cause of mortality in most of the developing countries. Recent times have seen an exceptional advancement in cancer biology Research. Researchers undertook the development of enormous chemotherapeutic agents. Pim family of serine/threonine kinases regulated by calcium/calmodulin have been identified as unique molecular targets in oncogenesis. It constitutes three members: Pim-1, Pim-2, and Pim-3 discovered by cloning the proviral integration site in Moloney murine leukemia virus (M-MuLV). Pim-1 was found to bear two isoforms Pim-1S and Pim-1L. It plays a dominant role in various processes of cell regulation like replicative senescence, drug resistance, apoptosis, epidynamics regulator, diagnostic tool, prostate cancer biomarker, and an immunotherapy agent. An insight into the structure of Pim kinases by crystal studies laid down a molecular basis for the development of selective and synergistic anti-cancer therapies. These proto-oncogenes are overexpressed in B lymphoid, myeloid cell lines, hematopoietic malignancies, and prostate cancer. This review emphasizes the importance and role of Pim-1 kinase in various molecular signaling pathways involved in tumorigenesis and the potential Pim-1 inhibitors reported so far.
P. S. Harshita, P. S. Yasaswi, V. Jyothi and T. S. Jyostna *
Department of Pharmaceutical Chemistry, Sarojini Naidu Vanita Pharmacy Mahavidyalaya, Tarnaka, Secunderabad, Telangana, India.
16 September 2019
11 January 2020
02 March 2020
01 June 2020