PLGA: A POLYMER OF CHOICE AS NANOCARRIER’S TO ACHIEVE EFFECTIVE DELIVERY OF MEDICINAL SUBSTANCESAbstract
Poly (D,L-lactide-co-glycolic acid) the first synthetic biodegradable polymer used in surgery as resorbabe material, is also approved by USFDA for use in drug delivery. The nanoparticle composed of PLGA can be used for both controlled and targeted drug delivery. There are various grades of PLGA which are having different biodegradation characteristics such as degradation takes place in several days to years. Thus one can develop a nanoparticulate delivery system with desired characteristics like Biodegradation, Biocompatibility, Particle size, Surface property, Drug release, Targetability and Immunogenicity. This review focus on the PLGA, its characteristics, Method of preparation of nanoparticles for lipophillic and hydrophilic drugs and the use of nanoparticles via different routes to target various disease conditions.
Ajay Verma*, Sanjay Ratnawat , Arun K. Gupta and Sanjay Jain
Assistant Professor, Smriti College of Pharmaceutical Education , Dewas Naka, Indore (MP), India
11 June, 2012
21 November, 2012
29 November, 2012
01 December, 2012