PLURONIC LECITHIN ORGANOGELS: AN EFFECTIVE TOPICAL AND TRANSDERMAL DRUG DELIVERY SYSTEMAbstract
Pluronic lecithin organogels (PLOs) are thermo-dynamically stable, biocompatible, viscoelastic with improve drug permeation and localised action. PLOs have gained much popularity compared with other traditional topical and transdermal drug delivery system owing to their lower cost, flexibility of dose and longer contact time. PLOs enhances the permeability of drugs because of desired drug partitioning, modification of skin barrier system by its components and biphasic drug solubility that is it enhanced solubility of poorly soluble drugs and increased penetrability of hydrophilic drugs. In this review we discuss the insights of PLOs as topical and transdermal drug delivery system.
S. Saha, R. Shivarajakumar and V. V. S. R. Karri *
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS Academy of Higher Education and Research, Mysuru, Tamil Nadu, India.
13 March, 2018
22 May, 2018
20 June, 2018
01 November, 2018