POLYPHENOLS AS ADJUVANT IN TOSSING OUT ACNE VULGARIS (PUSTULES): A NOVEL FORMULATION STRATEGY
AbstractAcne vulgaris is a skin condition in which people lose their self-esteem and ultimately lead to depression. It is more common among the adolescent age groups. According to GBD (Global burden of disease) study, about 85% of the populations are being affected. Various medications are available for the treatment, but, its uses are limited due to side effects like skin irritation. In our study, we have formulated a novel combination nanoemulsion gel containing adapalene and resveratrol for the treatment of pustules, assuming that it won’t produce much skin irritation and also expecting a synergistic activity. The spontaneous emulsification method was employed for the preparation of nanoemulsion, and it was incorporated into carbopol 934 gel. Further, various evaluation tests, including in-vitro and in-vivo studies, were performed. Cumulative percentage drug release was more for marketed formulation as compared to prepared formulation, whereas, the prepared formulation had a better efficacy as compared to marketed formulation. Thus, we can say that the formulation has exhibited its synergistic activity on combining with a polyphenol. Additionally, as an outcome of the skin irritation study, the formulation did not produce any skin irritation. Hence, we can conclude that the novel formulation containing adapalene and resveratrol served as a better candidate for the management of acne (pustules).
Article Information
16
845-852
773
596
English
IJPSR
S. K. Janani, R. S. Kumar *, S. S. N. Upadhyayula and C. Karthika
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamil Nadu, India.
sureshcoonoor@jssuni.edu.in
28 January 2020
17 May 2020
21 May 2020
10.13040/IJPSR.0975-8232.12(2).845-52
01 February 2021