POLYSACCHARIDE MATRIX TABLET FOR COLON SPECIFIC DRUG DELIVERYAbstract
The objective of the present study was to prepare a matrix tablet for colon targeting. Natural gaums (guar gum and xanthan gum) were used for the preparation of colon targeted drug delivery system. Different concentrations of guar gum and xanthan gum and their combinations were tried for the purpose. The prepared tablets were evaluated for in-process parameters as well as colon targeting characteristics. The colon targeting properties were evaluated by analysing the formulations for drug release in physiological pH medium of colon. All the formulations were found to be suitable in in-process quality control parameters. The guar gum and xanthan gum were used from 10% to 30% concentration in the formula. The third series of formulations contained guar gum and xanthan gum combinations in ratios of 10% and 20%, 20% and 10% and 15% and 15% respectively. The drug release was found to be 82% to 100% for guar gum formulations, 85% to 99% for xanthan gum formulations and 87% to 100% for the combination of xanthan gum and guar gum. The dissolution study shows that both the natural gums are suitable for use to develop colon targeted drug delivery system.
Amit Kumar Panigrahi*, Mathrusri M. Annapurna and K. Himasankar
FARGEM Pharmaceutical Research and Development Center, Düzce, Turkey
11 June, 2012
18 September, 2012
26 September, 2012
01 October, 2012