POSTNATAL DEVELOPMENT OF STOMACH IN SWISS MICE INDUCED BY LEAD ACETATEAbstract
Histopathological changes in developing stomach caused by lead acetate exposure at different days of the postnatal development were investigated in Swiss mice. In this study, pregnant Swiss mice were exposed to 533 mg/kg BW of lead acetate from 10th day of gestation to 21st day of lactation. The pups of exposed groups were sacrificed at 1, 7, 14 and 21 day of lactation period, and the effects of lead on histopathology of developing stomach were observed. Results of the present study showed that administration of lead to pregnant mice caused histopathological change in the stomach of developing pups. It is concluded that lead adversely affects the normal histology of developing stomach in pups exposed during gestation and lactation but it could not delay the major events of postnatal development.
Ragini Sharma, Isha Barber*, Khushbu Panwar and Amit Purohit
Environmental and Developmental Toxicology Research Lab., Department of Zoology, University College of Science, Mohanlal Sukhadia University, Udaipur- 313001, Rajasthan, India
20 June, 2013
13 August, 2013
10 October, 2013
01 November, 2013