POTENTIATIVE ACTIVITY OF CUCURBITA MAXIMA SEED EXTRACT WITH BETA VULGARIS & SMILAX REGELII ROOT EXTRACT TO REDUCE EXTRA FATS FROM THE BODYAbstract
Root Extracts of Beta vulgaris; Smilax regelii; & Cucurbita maxima. seed is effective for reducing fats individually as well as its combination effort through different mechanism. First one is used to flush out fats from the system and the second & third is used to regulate thyroxine. The extract of A,B & C were taken with diffusion extraction, ethanol extraction through soxhlet apparatus and through Kjeldahl extraction method. Toxicity LD50 study was taken into 15 mices in three divided categories – B, C and A&B&C gives 2.82+0.35, 4.48+0.130 & 2.82+0.277 respectively. Affectivity was evaluated to the extracts of Beet, Sarsaparilla, Pumpkin seed and its combination which gives 500 mg, 250 mg, 150 and 500 mg /kg/day, after administered orally, effectiveness to reduce fats were done in 5 guinea pigs giving results of mean weights 909.6 + 2.07 (control), 905.8 + 2.16 (extract-A), 906.42 + 2.24 (extract-B), 905.42 + 2.05 (extract-C), 905.42 + 2.05 (extract-B&C), 904 +1.499 (B&A), 902.53 + 1.7 (A&B&C). The t-test and the P value of C; B&C; A&B&C is 1.88, 3.209, 5.902 and 0.095, 0.0124 & 0.0004 respectively. So, the P value of C; B&C; and A&B&C recognized as – difference is consider not so statistically significant, statistically significant and extremely statistically significant. Thus it’s concluded that A&B&C are more effective in compare to B&C and C for fat reduction in guinea pigs.
RAKESH DAS *, JAGDISH SAHU, R.N. GUPTA
Department of Pharmaceutical Technology, Jadavpur University, Kolkata (West Bengal), India
04 January, 2010
18 January 2010
25 January, 2010
01 February, 2010