PRE-FORMULATION CHARACTERIZATION OF CHELATED AMINO ACID COMPLEXES
AbstractAmino acid chelated complexes were synthesized and characterized to determine their purity. The purity of the complexes was found to be ranging from 42-75%. The HPLC method for determination of free amino acid content in the complexes was developed and validated and found to be linear, precise and accurate within concentration range of 0.157 mg/mL to 20.14 mg/mL. The method was used to estimate the purity of the amino acid complexes. The changes in the carboxylate and amine group stretches in FT-IR indicated the association of metal ion with the amino acid. The initial studies described above demonstrated that the chelated complexes can produce sufficient osmotic pressure to be used as ergogenic aids
Article Information
7
2321-33
436
1959
English
IJPSR
B. Henriksen *, J. Tolman , N. Kathe and C. Johnson
College of Pharmacy , Manchester University, Fort Wayne, IN 46845, USA
bshenriksen@manchester.edu
19 January, 2016
24 April, 2016
08 May, 2016
10.13040/IJPSR.0975-8232.7(6).2321-33
01 June 2016
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