ANTIMICROBIAL AND TOXICITY STUDY OF DIFFERENT FRACTIONS OF DILLENIA INDICA LINN. BARK EXTRACT
AbstractThe methanolic extract along with some organic soluble fractions of the bark of Dillenia indica Linn. were tested against four Gram-positive and seven Gram-negative bacteria and against three pathogenic fungi. n-Hexane and dichloromethane fractions showed remarkable activities against all the tested bacteria but n-Hexane fraction showed highest activity against Shigella dysenteriae and its zone of inhibition was 15.51 ± 0.75 mm. Other showed moderate or little activity. Methanol crude extract showed highest activity against fungus Candida albicans with a zone of inhibition 13.13±1.75mm. Lowest minimum inhibitory concentration (MIC) values were observed in n-hexane fraction against Shigella dysenteriae and Staphylococcus aureus and were 0.312 in both cases. Lowest LC50 value 19.02±1.16 of n-hexane fraction indicated the highest toxicity in comparison with the other fractions
Article Information
17
860-866
480
1446
English
Ijpsr
M. Badrul Alam, Nargis S. Chowdhury, M. E. H. Mazumder, M. Ekramul Haque*4
Department of Pharmacy, BRAC University, 66-Mohakhali, Gulshan, Dhaka, Bangladesh
11 December, 2010
21 January, 2011
02 March, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(4).860-66
01 April, 2011
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