PREDICTORS OF POLYPHARMACY PRESCRIPTION IN TYPE 2 DIABETES MELLITUS PATIENTS: A CROSS-SECTIONAL SURVEYAbstract
Polypharmacy is defined as the “prescription, administration, or use of more medications than are clinically indicated. It can lead to drug-drug interactions and result in adverse drug events. Therefore, this study aimed to determine the prevalence of polypharmacy and factors that independently predict polypharmacy prescription. 200 Type 2 Diabetes Mellitus (T2DM) patients were enrolled and analyzed. The overall prevalence of polypharmacy was 51%, with the average number of drugs prescribed being 4.68 ± 3.18. The odds of polypharmacy prescription increased with the duration of T2DM, with comorbid conditions, and were higher in patients with uncontrolled glycaemic status. At the same time, the other factors, gender, smoking, and alcohol habits, did not reveal any significant association with polypharmacy prescription. Thus the most common predictors of polypharmacy prescription found were duration of T2DM, comorbid conditions, and glycaemic status of the patient. The findings of this study would be helpful in Government programs in developing, evaluating, and implementing interventions for supporting medicines optimization and deprescribing in India.
Brijalkumar S. Patel *, Archanabahen G. Chaudhari and Jayshree C. Patel
Department of Pharmacology, GMERS Medical College, Valsad, Gujarat, India.
25 August 2022
18 October 2022
17 November 2022
01 May 2023