PRELIMINARY ANTIMICROBIAL ACTIVITY AND CYTOTOXICITY OF PLANT EXTRACTS (ROOTS) OF COCCINIA GRANDIS (FAMILY: CUCURBITACEAE) hAbstract
In the present study, the in vitro antimicrobial and cytotoxic activity of root extract of Coccinia grandis were evaluated. Ethanolic crude extract with its various solvent soluble fractions of C. grandis showed significant antimicrobial activity by disc diffusion method on some gram positive and gram negative bacteria. The extracts exhibited 9-12 mm (approximately) of zone of inhibition comparing with standard ciprofloxacin (15-19 mm). In the brine shrimp lethality bioassay, the crude ethanolic extract showed significant cytotoxicity with LC50 of 2.496 mg/ml in comparison to vincristine sulphate (LC50 value 0.451 mg /ml).
Md. Hasanuzzaman , Md. Shahadat Bin Sayeed , Md. Siddiqul Islam , Md. Shahid Sarwar , Md. Mizanur Rahman Moghal , Jami Uddin Ahmed and Mohammad Safiqul Islam*
Assistant Professor, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
20 December, 2012
30 January, 2013
22 March, 2013
01 April, 2013