PRELIMINARY PHYTOCHEMICAL, ANTI-BACTERIAL, ANALGESIC, ANTI-DIARRHOEAL AND CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACT OF POLYALTHIA SUBEROSA LEAVESAbstract
The MeOH extract of leaves of Polyalthia suberosa Roxb. (Annonaceae) was screened for its antibacterial, analgesic, Antidiarrhoeal and cytotoxic activities. The extract showed moderate anti-bacterial activity against Vibrio cholerae, Sheigella sonnei, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus saprophyticus. It also produced significant (P<0.01) writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500 mg/kg, which was comparable to the standard drug diclofenac sodium. Moreover, when tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it decreased the frequency of defecation and increased mean latent period significantly (P<0.01) at the dose of 500 mg/kg comparable to the standard drug loperamide. The extract also exhibited high level of cytotoxicity in brine shrimp lethality bioassay (LC50: 30 µg/ml). The overall results tend to suggest the antibacterial, analgesic, antidiarrhoeal and cytotoxic activities of the extract.
Sm. Faysal Bellah , Firoj Ahmed , A.A. Rahman , I.Z. Shahid and S.M. Moazzem Hossen*
Lecturer, Department of Pharmacy, University of Science & Technology Chittagong, (USTC), Foy’s Lake, Kulshi, Chittagong 4202, Bangladesh
16 January, 2012
24 February, 2012
19 April, 2012
01 May, 2012