PRELIMINARY SCREENING AND EVALUATION OF COMMIPHORA CAUDATA LEAF EXTRACT ON CARIOGENIC PATHOGENSAbstract
Cariogenic organisms are responsible for producing and developing tooth decay, which ends up in dental caries. It is commonly seen in both children and adults. The aim was to evaluate anticariogenic activity of Commiphora caudata leaf extract. Two different solvents such as acetone and 70% ethanol used against Lactobacillus casei and Streptococcus mutans. Agar well diffusion method and minimum inhibitory concentration (MIC) was used for this purpose. Ethanolic extract showed significant antibacterial activity against the tested organisms. Preliminary phytochemical screening of the extract revealed the presence of steroids, phenols, flavonoids and coumarins in both acetone and ethanol extract. The above observations remarkable cariogenic inhibition, which may be due to these active secondary metabolites. This may potentially treat dental caries and be used as lead(s) molecules in the development of new antimicrobial drugs against cariogenic pathogens.
Subbulakshmi Packirisamy *, Bettina Lavanya Magdaline, Anandhi Dhanavel, Deepa Rajendiran and R. J. Vijayashree
Department of Pharmacology, Maduravoyal, Chennai, Tamil Nadu, India.
26 February 2022
09 April 2022
25 April 2022
01 October 2022