PREPARATION AND CHARACTERISATION OF LORNOXICAM LOADED TRANS-FEROSOME: A NOVEL CARRIER FOR ENHANCED TRANSDERMAL DELIVERYAbstract
To study and investigate transfersomes as a transdermal delivery system for the poorly soluble drug, Lornoxicam-loaded transfersomes were prepared with non-ionic surfactants like span 80 and tween 80 by the rotary evaporation-sonication method. Drug & polymer was dissolved in an organic solvent mixture of chloroform and ethanol (1:1, v/v). The outcome of the work is that prepared formulations were characterized for particle size analysis, drug entrapment, optical, phase contrast and transmission electron microscopy, in-vitro drug release through cellophane membrane, and drug release kinetic studies. FTIR studies showed compatibility of the drug with excipients. Based on the entrapment efficiency, drug content and in-vitro release studies, the formulation S2 containing span 80 (4% w/w) was selected for permeation studies through albino mice skin and compared with the pure lornoxicam solution. The cumulative percentage of lornoxicam permeated in all formulations was significantly (p<0.05) higher than the pure drug solution. Parameters like vesicular size, zeta potential, and drug entrapment were evaluated after one month. The study substantiated that the transfersome can be used as a feasible alternative formulation of Lornoxicam with advanced permeation characteristics for transdermal application.
Anand K. Srivastava and Nimisha *
Amity Institute of Pharmacy, Lucknow, Amity University Uttar Pradesh, Sector 125, Noida, Uttar Pradesh, India.
24 February 2022
21 June 2022
08 September 2022
01 October 2022