PREPARATION AND CHARACTERIZATION OF AN OILY SUSPENSION OF OMEPRAZOLE FOR ADMINISTRATION IN PEDIATRICSAbstract
The present research was focused on the development of an oily suspension for oral administration of omeprazole in Pediatrics. Currently, for the treatment of this population, extemporaneous preparations are used in hospitals with many limitations in their use as bad organoleptic features and loss of drug activity due to improper manipulation, causing the omeprazole to be sensitive to the acidic environment of the stomach, with the consequent loss of activity. The objectives are to achieve a stable formulation of omeprazole in normal storage conditions and to ensure that this formulation maintains the active ingredient protected from the hostile environment of the stomach, which causes degradation of the drug. An oily omeprazole suspension was elaborated and compared to three master formulas usually employed in hospitals (pellets suspension, xanthan suspension, Ora-Sweet®suspension). The omeprazole suspension has been characterized as follows: appearance and organoleptic characteristics, content uniformity test, viscosity, study of dissolution rate and formulation stability.
M. R. Cruz-Sanmartín*, J. I. Pérez-Martínez and A. M. Rabasco-Álvarez
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Sevilla. 41012 – Sevilla, Spain
16 April, 2015
08 July, 2015
30 July, 2015
01 October, 2015