PREPARATION AND CHARACTERIZATION OF HERBAL NANOFORMULATION CONTAINING ANDROGRAPHIS PANICULATA EXTRACTAbstract
This study aimed to investigate the preparation and characterization of polymeric nanoparticles containing extract of Andrographis paniculata using Eudragit S 100 polymer. The methanolic extract of aerial parts of Andrographis paniculata Nees (Acanthaceae) was prepared and standardized for andrographolide content using the High-Performance Liquid chromatography technique. Three formulations containing 50, 100 and 150 mg of extract were prepared by solvent displacement method. Parameters including drug: polymer ratio, stabilizer, solvent, and stirring speed were optimized. Characterization of the formulations was carried out using particle size analysis, PDI, DSC, X-RD, SEM techniques, entrapment efficiency and in-vitro drug release studies. The particle size of the nanoformulations was found to be within the range of 300-400 nm, with entrapment efficiency more than 75% and drug release more than 55% after 8 h. Aerial parts extract of Andrographis paniculata was embedded and dispersed in Eudragit S 100 polymer as smooth spherical nanoparticles which may prove to be a novel drug delivery system.
A. U. Devi * and S. Khanam
Department of Pharmacognosy, Moulana College of Pharmacy, Angadippuram, Perinthalmanna, Malappuram, Kerala, India.
06 March 2019
17 June 2019
16 November 2019
01 December 2019