PREPARATION AND CHARACTERIZATION OF MESALAMINE SOLID DISPERSIONS BY KNEADING METHODAbstract
The purpose of the study was to improve the physicochemical properties of Mesalamine like solubility and dissolution rate by forming solid dispersions with sodium lauryl sulphate (SLS) and Urea (UR) as water-soluble carriers. The solid dispersion of Mesalamine by kneading method were prepared using 1:1, 1:2 and 1:3 ratios of drug to polymer using methanol as solvent. Characterization of Mesalamine solid dispersion was performed by Fourier Transform Infrared (FTIR) spectroscopy and X-ray powder diffractometry study. FTIR spectra reveal that there was no drug – carrier interaction and absence of Mesalamine peaks in XRD profile suggests the transformation of crystalline Mesalamine to amorphous form. The saturation Solubility study was carried out by using flask shaker method at room temperature. Dissolution study was conducted in 0.1N HCl at 37oC ± 0.5oC using USP type II (paddle) type dissolution apparatus. The prepared dispersion showed marked increase the saturation solubility and dissolution rate of Mesalamine than that of drug alone. Therefore the dissolution rate of poorly water soluble drug Mesalamine can be significantly enhanced by the preparation of solid dispersion using SLS and UR by kneading technique.
Lalit Jejurkar* and K. K. Tapar
Vidyabharti College of Pharmacy, Department of Pharmaceutics (PG & Research), Amravati, Maharashtra, India
07 June, 2011
23 July, 2011
28 September, 2011
01 October, 2011