PREPARATION AND CHARACTERIZATION OF NYSTATIN-LOADED SOLID LIPID NANOPARTICLES FOR TOPICAL DELIVERYAbstract
Solid lipid nanoparticle proved appropriate as prolonged release formulation for lipophilic drugs. The present work dealt with the preparation of the antifungal lipophilic drug nystatin into solid lipid nanoparticles ((Nyst-SLNs).) formulation for topical delivery with the aim to prolong its release and effectiveness. Hot homogenization and ultrasonication were applied in the production of (Nyst-SLNs). Different matrix material and stabilizers were tested. All the formulations were subjected to particle size analysis, zeta potential, drug entrapment efficiency and in-vitro release studies. Transmission electron microscopy was conducted to investigate the morphology of nystatin loaded nanoparticles. The differential scanning calorimetry visualized the dispersed amorphous state of nystatin in the SLN. In addition, the present study addresses the compositions of different formulation on the physicochemical properties and drug release profile of Nyst-SLNs.
Rawia Khalil*, Mahfouz Kassem , Ahmed A. Elbary , Mohamed El Ridi and Mona AbouSamra
Department of Pharmaceutical Technology, National Research Centre, Dokki, Cairo, Egypt
14 February, 2013
23 March, 2013
28 May, 2013
01 June, 2013