PREPARATION AND CHARACTERIZATION OF pH BASED CARBOPOL 934P IN-SITU HYDROGELS FOR THE TREATMENT OF HARMFUL BACTERIAL INFECTIONSAbstract
The purpose of the present study describes the preparation of pH based in-situ gel formulations were applied for the harmful bacterial infections by using carbopol 934P and HPMC derivatives. The simple procedure was adopted for preparing these formulations. To eliminate or reduced adverse systemic effects produce from bacterial conjunctivitis, topical route of administration, such as eye drops was preferred for this type of infections and it should be installed into the eye’s cornea. These eye drops are more effective to provide therapeutic index and also to achieve good bioavailability in the eye. Forthcoming, the developed in-situ gel formulations were characterized by gelling capacity, pH, clarity, appearance, viscosity determination, surface tension, drug content, in-vitro drug release, HET-CAM study, permeation study, and in-vivo ocular irritation study. The optimized formulation (F2) was set up to be non-irritant and well tolerable from the results both in-vitro HET-CAM study and ocular irritation study. The developments in-situ gel formulation forms good gelling capacity, clear/translucent in appearance, after administration in the eye. The developed in-situ gel formulations control the precorneal drainage, increased resistance time on the eye, improved patient compliance by increasing the bioavailability of drug concentrations to the eye.
B. Anbarasan, R. S. Kumar, J. Thanka, S. Ramaprabhu and S. Shanmuganathan *
Department of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
09 May 2018
03 October 2018
24 November 2018
01 January 2019