PREPARATION AND EVALUATION OF GLIPIZIDE MICROSPHERES USING MUCOADHESIVE POLYMERSAbstract
Microspheres are the carrier linked drug delivery system in which particle size ranges from 1-1000μm. Microspheres constitute an important part of drug delivery systems by virtue of their small size and reliable means to deliver the drug to the target site with specificity. However, the advantages of microspheres are limited due to their short residence time at site of absorption. This can be achieved by coupling bioadhesion characteristics to microspheres and developing “mucoadhesive microspheres”. Glipizide is an oral hypoglycemic drug with short half-life. So to provide prolonged action glipizide microspheres were prepared by ionic gelation technique using different concentration of mucoadhesive polymers. The prepared microspheres were characterized for various physicochemical prarameters such as particle size, percentage yield, encapsulation efficiency, scanning electron microscopy, in-vitro drug release and kinetics study. The in-vitro drug release studies were performed in buffer media and shown the controlled release pattern of drug up to 10 hours. Drug release from the microspheres was found following zero order release kinetics with non-fickian release mechanism. The satisfactory results were obtained in all prepared formulations and based on the results F6 was best one when compared to other formulations.
S. Mohapatra*, S. Sen and S. C. Si
School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar-751003, Orissa, India
14 August, 2013
20 September, 2013
17 December, 2013
01 January, 2014