PREPARATION AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF SODIUM VALPROATEAbstract
Mucoadhesive microcapsules of sodium valproate, an anticonvulsant used in the treatment of epilepsy and in migraine, have been prepared from sodium alginate, hydroxypropylmethyl cellulose-K4M, carbopol 934P & sodium CMC using 10% w/v calcium chloride solution by ionic gelation method. Drug: polymer ratios were 1:1 in all the formulations and polymer mixtures employed were 4:1, 5:1, 6:1, 7:1 of sodium alginate: polymer (hydroxypropyl methyl cellulose-K4M, carbopol 934P & sodium CMC). Calcium chloride was used for ionic gelatin and cross linking of sodium alginate molecules. Microcapsules were spherical in shape and of sizes between 798 microns to 952 microns. Carbopol 934P was found most effective in controlling drug release from microcapsules followed by sodium CMC. Drug release found to be best from the formulation developed with carbopol 934P and followed Super case II transport.
Niranjan Kumar Manna* and Subas Chandra Dinda
Professor, FL-402, 112, Kalicharan Ghosh Road, Kolkata-700050, India
30 May, 2011
20 August, 2011
28 August, 2011
01 September, 2011