PREPARATION AND EVALUATION OF PARACETOMOL MUCOADHESIVE BUCCAL PATCHES USING TAMARIND SEED POLYSACCHARIDE AS A NATURAL BINDERAbstract
Mucoadhesive buccal patches provide a wide variant of therapeutic effect via mucosa and buccal region of the mouth. They provide zero first pass metabolism and high bioavailability providing patient compliance. In the present study, buccal patches of paracetamol were developed to improve the bioavailability and half life of the drug. In the process of its preparation binder plays a greater role in holding the drug. One of such is Tamarind seed polysaccharide (TSP) isolated from the kernels of Tamarindus indica seeds was used as a binder in the preparation of paracetamol mucoadhesive buccal patches. Here, solvent casting method was employed and performed various evaluation parameters. Mucilage extracts at 0.5,1, 1.5, 2, 2.5% concentrations were used. All the patches were shown smooth surface and elegant texture. The weights of (10 mm) patches were in the range of 21.6 to 26.8 mg. The results indicate that the formulation with 2% mucilage extract shows maximum drug release. Among the five formulations (F1 to F5), F4 formulation showed maximum percentage of drug release.
P. Neeraja *, Uma Devi P., V. Sandhya, M. Shanjana, Umool Viqar Sameera and Shreya Deshpande
Geethanjali College of Pharmacy, Cheeryal (V), Keesara (M), Ranga Reddy, Telangana, India.
30 October, 2016
27 December, 2016
31 December, 2016
01 May, 2017