PREPARATION, CHARACTERIZATION AND EVALUATION OF RESVERATROL-LOADED PEGYLATED PLGA NANOPARTICLES
AbstractThis study focuses on preparing and evaluating polymeric nanoparticles made of pegylated PLGA. In this study, both double-emulsion solvent evaporation and single-emulsion solvent evaporation were employed to formulate the pegylated PLGA nanoparticles with PVA as the surfactant. For the encapsulation of the hydrophobic drug Resveratrol, formulations were successfully prepared and tested for their particle size, polydispersity index, zeta potential, drug loading and entrapment efficiency. Scanning electron microscopy was used to observe the morphology and surface characteristics of the nanoparticles. The results demonstrated successful fabrication of the Resveratrol loaded pegylated PLGA nanoparticles. PVA was demonstrated in the present study to be a promising surfactant for the encapsulation and delivery of poorly water-soluble compounds as pegylated PLGA nanoparticles with the desired particle size, morphology and drug loading. PLGA nanoparticles encapsulated with Resveratrol had been successfully used to deliver the drug to the target site by pegylated PLGA nanoparticles.
Article Information
26
2877-2886
1251 KB
275
English
IJPSR
Shashi Ranjan * and Subas Chandra Dinda
Department of Pharmaceutics, College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
ranjanshashi20@gmail.com
08 October 2022
16 November 2022
18 November 2022
10.13040/IJPSR.0975-8232.14(6).2877-86
01 June 2023
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