PREPARATION, CHARACTERIZATION AND EX-VIVO HUMAN SKIN PERMEATION OF IBUPROFEN-SOLUPLUS POLYMERIC NANOMICELLESAbstract
Ibuprofen is a widely used non-selective non-steroidal anti-inflammatory drug. Ibuprofen oral use is restricted by its potential gastric toxicity, which can be overcome utilizing alternative drug delivery routes. A novel micellar transdermal delivery of Ibuprofen was readily prepared herein using the solubility enhancing co-polymeric excipient polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®). Ibuprofen polymeric micelle systems were prepared at a wide range of concentrations and characterized by particle size analysis, rheology measurement, infrared spectroscopy, and differential scanning calorimetry. Nanosize micelles were obtained (< 100 nm), with a small polydispersity index, at 0.5 – 2% concentration range of Soluplus®. The aqueous solubility of Ibuprofen was significantly enhanced in Soluplus®micelle system. The highest solubility was achieved at a concentration of 2% of Soluplus® with an approximate ten-fold increase in solubility. Moreover, statistical analysis of Ibuprofen’s permeation from Ibuprofen polymeric micelle systems against a control sample revealed an increase in the cumulative drug permeation with increasing polymer concentration.
F. Al-Akayleh *, Z. Zakari, S. Adwan and M. Al-Remawi
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Jordan.
24 May 2020
21 October 2020
25 October 2020
01 May 2021