PREPARATION OF CARBAPOL COATED NANOPARTICLES BY EMULSION POLYMERIZATION TECHNIQUE
AbstractNowadays there has been considerable interest in developing new routes alternative to injection for delivering macromolecules such as proteins and peptides. However, peptides and protein drugs are degraded before they reach the blood stream and can not cross the mucosal barrier. The mucoadhesive polymer coated nanoparticles can solve these problems. They were prepared by emulsion polymerization. Methyl methacrylate polymerized in the presence of polysaccharide such as carbapol leads to formation of mucoadhesive polymer coated nanoparticles. The mucoadhesive polymers could interact with the mucus glycoproteins which allow the mucoadhesive system to remain adhesive for an extended period of time. Coating nanoparticles with them improved their mucoadhesion. These mucoadhesive polymer coated nanoparticles are suitable for carrying hydrophilic drugs. In present study carbapol coated nanoparticles are prepared by emulsion polymerization technique. Particle size was measured by Scanning electron Microscope. The effect of polymer concentration and chemical initiator concentration on the resultant nanoparticles was studied
Article Information
30
1786-1789
586
929
English
Ijpsr
Krishna A. Sailaja *, P. Amareshwar and M.Dakshayani
University College of Technology, Osmania University, Hyderabad, Andhra Pradesh, India
11 April, 2011
17 May, 2011
27 June, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(7).1786-89
01 July, 2011
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