PREPARATION & PHYSICOCHEMICAL CHARACTERIZATION OF POORLY WATER SOLUBLE DRUG BY USING SPRAY DRYING AND SOLVENT EVAPORATION METHODSAbstract
Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. The various preparation techniques for solid dispersion and compiles some of the recent technology transfers. This research article investigates enhancement of the dissolution profile of atorvastatin using solid dispersion with PVP. The article also describes the preparation of fast-dissolving atorvastatin by using water soluble polymer. Polyvinyl pyrrolidone (PVP K-30) was selected and solid dispersions were prepared by the method of spray drying and solvent evaporation. Dissolution studies using the USP paddle method were performed for solid dispersions of atorvastatin. Infrared (IR) spectroscopy, differential scanning calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. Dissolution of atorvastatin improved significantly in solid dispersion products. Thus, the solid dispersion technique can be successfully used for improvement of dissolution of atorvastatin.
Sunita S. Shinde*, Amol S. Shete , Manisha V. Patil , Sharad Salunkhe and Deepak Indapure
Department of Pharmaceutics, Tatayasaheb Kore College of Pharmacy, Warananagar, Maharashtra, India
27 June, 2013
26 December, 2013
07 February, 2013