PREVENTIVE ANTI-INFLAMMATORY ACTIVITY OF AN AQUEOUS EXTRACT OF LARREA DIVARICATA CAV. AND DIGESTIVE AND HEMATOLOGICAL TOXICITYAbstract
Larrea divaricata Cav. commonly known as “jarilla hembra” is used in folklore medicine as anti-inflammatory. There was no scientific evidence justifying the medicinal use of the aqueous extract for inflammation diseases. Nowadays, there are two principal types of anti-inflammatory drugs: Steroidal anti-inflammatory drugs (corticosteroids) and non-steroidal anti-inflammatory drugs (NSAIDs), which exert gastrointestinal ulceration and bleeding. In this work the preventive anti-inflammatory activity of L. divaricata aqueous extract (AE) in C3H/He mice was determined by carrageenan- induced inflammation and ear edema tests, also its toxicity on gastric tissues and on blood cells was studied. The chromatographic profile showed: nordihydroguaiaretic acid (NDGA) as majority compound. AE exerted anti-inflammatory action without inducing gastric or blood cell toxicities. Also, it could modulate anti-inflammatory and pro-inflammatory cytokines. NDGA was not the compound responsible of the anti-inflammatory action. This work rescues the potentiality of AE as a gastric and blood cells innocuous anti-inflammatory agent and confirms its ethno- pharmacological uses.
Roberto Davicino, Ignacio Peralta , Renzo Martino, Rosario Alonso and Claudia Anesini *
Institute of Chemical and Drug Metabolism, University of Buenos Aires- National Council of Scientific and Technical Research (IQUIMEFA-UBA-CONICET), Buenos Aires, Argentina
18 December, 2014
19 February, 2015
05 April, 2015
01 August, 2015