PRONIOSOMAL DRUG DELIVERY SYSTEM- A REVIEW
AbstractProniosomes are provesicular dried or anhydrous formulations that are composed using non-ionic surfactants and solvents. The non-ionic surfactant’s hydrophilic portion orients outward to form a bilayer, while the hydrophobic portion moves inward. Medicines with hydrophilic properties are contained in vesicles, while hydrophobic drugs get embedded in proniosome bilayers. Proniosomes are physically stable while storage and handling when compared to liposomes and niosomes. They can be used to impart targeted drug action, enhance retention time, increase penetration of drug at target tissue, sustain/ control drug release and minimize side effects. These proniosomes can be rehydrated with hot aqueous solution and constant stirring and transformed to niosomes immediately when needed. Generally, proniosomes are either converted to niosomes or proniosomal gel for transdermal drug delivery to use of the benefits associated with proniosomes. This review article focuses on structure, mechanism of drug transport, composition, preparation, characterization methods of proniosomes and the research carried out in past in field of provesicular drug delivery system.
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