PROTECTIVE ACTIVITY OF SEMECARPUS ANACARDIUM FRUIT EXTRACTS AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN WISTAR RATSAbstract
The objective of the present investigation of hepatoprotective activity of various Fruit extract of Semecarpus anacardium in paracetamol induced liver damage model in Wistar rats. Liver damage was produced by paracetamol (2gm/kg, p. o.) in 1% CMC. The Plant extracts (200mg/kg, p. o.) were administered every 24 hrs for seven days, while standard group received N-acetyl l- cysteine. At the end of the study the marker enzymes in serum were analyzed. The aqueous as well as alcoholic extract showed significant hepatoprotective activity and efficacy of alcoholic extract was almost comparable to that of N-acetyl l- cysteine.
V A Kangralkar *, S C Burli and V S Nandagaon
Dept. of Pharmacology, Maratha Mandals College of Pharmacy , Belgaum (Karnataka), India
03 April, 2010
29 June, 2010
06 July, 2010
01 August, 2010