PROTECTIVE EFFECT OF AMARANTHUS SPINOSUS FOR ISCHEMIA REPERFUSION INJURY IN RAT BRAINAbstract
Cerebral ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demands. This leads to poor oxygen supply or cerebral hypoxia and thus leading to the death of brain tissues or cerebral infarction/ischemia stroke. It has been the third most common cause of death in developed countries; stroke can affect walking, talking, speech, vision, spatial awareness, swallowing, bladder control, bowel control, and balance co-ordination. The test drug Amaranthus spinosus leaves were defatted with petroleum ether (60-80 °C) and then extracted with hydroalcoholic solvent (Ethanol 95%, v/v: water, 1:1) by soxhlation process. The hydroalcoholic extract of the drug was evaluated for cerebroprotective activity in Wistar albino rats in the doses of 200 and 400 mg/kg by the Induction of cerebral ischemia/reperfusion followed by behavioural tests, infarct size measurement, and antioxidant activity. The test drug ASE produced the cerebroprotective activity in a dose-dependent manner.
M. Abid * and N. A. Khan
Department of Pharmacology, School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India.
17 October 2019
06 April 2020
27 August 2020
01 October 2020